FORESEE PHARMACEUTICALS PRESENTED POSTER ON MMP-12 INHBITOR, FP-020, IN GENETIC MODEL OF SARCOIDOSIS AT THE WASOG 2023 INTERNATIONAL CONFERENCE ON SARCOIDOSIS AND INTERSTITIAL LUNG DISEASES (ILDs)

"We are very enthusiastic about the data in this poster, as it strongly validates MMP-12 as a potential target for cardiac sarcoidosis and strongly corroborates the evidence amassed to date, both by our group and collaborators, supporting a potentially pivotal role of MMP-12 biology in the pathophysiology of sarcoidosis and other diseases with immune-fibrotic and granulomatous components". "FP-020 is one of the most efficacious drugs we have tested in our sarcoidosis disease models", said Dr. Weichhart.

"We are very enthusiastic about the data in this poster, as it strongly validates MMP-12 as a potential target for cardiac sarcoidosis and strongly corroborates the evidence amassed to date, both by our group and collaborators, supporting a potentially pivotal role of MMP-12 biology in the pathophysiology of sarcoidosis and other diseases with immune-fibrotic and granulomatous components". "FP-020 is one of the most efficacious drugs we have tested in our sarcoidosis disease models", said Dr. Weichhart.

Additionally, Dr. Culver stated: "When putting in perspective this new exciting data where we observe a therapeutic benefit from FP-020 across multiple underlying components of the disease, both immune and fibrotic, and combining it with the existing body of non-clinical data as well as human expression data showing that MMP-12 is one of the most overexpressed protein in sarcoidosis patients, we remain very enthusiastic about the promise of Foresee's MMP-12 inhibitors as a potential unique treatment approach for sarcoidosis and ILDs.

Key Highlights from the Poster

Poster Talk Session: Session 2, Tuesday June 20

Time: 15:32 CET

Location: Aula Medica, Stockholm, Floor 2

Poster number: 4998-A-2326

(https://mkon.nu/wasog2023/poster_talks_sessions)

The poster is available at Foresee's corporate website: https://www.foreseepharma.com/en-us/event/20

About Foresee Pharmaceuticals Co., Ltd.

Foresee is a Taiwan and US-based biopharmaceutical company listed on the Taipei Exchange (6576.TWO). Foresee's R&D efforts are focused in two key areas, namely its unique stabilized injectable formulation (SIF) long-acting injectable technology with derived drug products targeting specialty markets and secondly, its transformative preclinical and clinical first-in-class NCE programs targeting rare and severe disease areas with high unmet needs.

Foresee's product portfolio includes late and early-stage programs. CAMCEVI® 42 mg, for the treatment of advanced prostate cancer, is now approved in the U.S., Canada, and EU, and launched in the U.S. in April, 2022. Additionally, U.S. and EU regulatory submissions are under preparation for CAMCEVI® 21 mg, the U.S. regulatory submission is anticipated in 2024. The second indication of CAMCEVI® 42 mg– central precocious puberty (CPP), the phase 3 clinical study is currently being initiated. FP-025 – a highly selective oral MMP-12 inhibitor targeting inflammatory and fibrotic diseases, a Phase 2 proof-of-concept study in allergic asthmatic patients, the study has been completed with positive outcome. FP-045 – a highly selective oral small molecule allosteric activator of ALDH2, a mitochondrial enzyme, for which a Phase 1b/2 Fanconi Anemia study is currently being initiated, and a P2 study in pulmonary hypertension group 3 patients is in planning. www.foreseepharma.com

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