Treating COVID with Metformin Reduces Long COVID Rates

"The results of this study are important because Long COVID can have a significant impact on people's lives," said Carolyn Bramante, MD, principal investigator and an assistant professor at the University of Minnesota Medical School. "Metformin is an inexpensive, safe and widely available drug, and its use as a preventive measure could have significant public health implications." "The results of this study are important because Long COVID can have a significant impact on people's lives," said...

"The results of this study are important because Long COVID can have a significant impact on people's lives," said Carolyn Bramante, MD, principal investigator and an assistant professor at the University of Minnesota Medical School. "Metformin is an inexpensive, safe and widely available drug, and its use as a preventive measure could have significant public health implications."

Previous data suggested that metformin's anti-inflammatory and anti-infectious properties could treat COVID-19 infection. The antiviral effect was confirmed in a recent analysis of the viral load of COVID-OUT study participants, which is currently available as a preprint. Researchers reported a 3.6-fold decrease in the SARS-CoV-2 virus level in people who received metformin instead of placebo.

Three years into the pandemic, more than 6.8 million people worldwide have died of the virus, and countless people still suffer from Long COVID. As the first COVID treatment proven to reduce Long COVID in a randomized controlled trial, metformin is safe, accessible and low-cost. Metformin is also one of the most commonly prescribed medications in the United States and globally, taken by more than 150 million people each year. This new treatment option is especially important for the approximately one in three patients who cannot take Paxlovid (Pfizer's groundbreaking COVID treatment) because of conflicting medications or health conditions.

"Access to affordable COVID treatment is a global justice issue. We hope the U.S. and other nations update their guidelines to include metformin as a treatment option for people with COVID-19," added Elaine Lissner, founder and trustee of the Parsemus Foundation, a research funder part of the nonprofit coalition funding the trial. "This would be the first universally available treatment, giving more people a tool to combat the disproportionate impact of this disease."

The Parsemus Foundation works to create meaningful improvements in human and animal health and welfare by advancing innovative and neglected medical research. The foundation has supported rigorous clinical studies on the effectiveness of existing medications to treat COVID infection, including enrollment support and bilingual outreach for the University of Minnesota's COVID-OUT trial. For more information, see https://www.parsemus.org/humanhealth/covid-19/.

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