Scienza e Tecnologia
First Patient Enrolled in ProstACT TARGET Study
The TARGET study, a collaboration between Telix and research partner, GenesisCare, is exploring the potential of TLX591 in combination with external radiation in patients at an earlier stage in their prostate cancer, providing direction for future indication expansion. The study, which targets enrolment of 50 patients across multiple Australian sites, enrolled the first patient at GenesisCare's integrated cancer centre at the St John of God Hospital Murdoch campus in Western Australia . The clinical trial is being run through GenesisCare's global Contract Research Organisation and its Australian network of dedicated theranostics centres.
The third concurrent study in the ProstACT program, ProstACT SELECT, is a theranostic (imaging and therapy) Phase I radiogenomics study to demonstrate the utility of Telix's imaging agent Illuccix (kit for the preparation of gallium-68 ( Ga) Glu-urea-Lys(ahx)-hbed-CC, also known as Ga-PSMA-11 injection) to select patients for TLX591 therapy given as two doses 14 days apart.
Principal Investigator for the ProstACT TARGET study and GenesisCare Group Medical Director (Theranostics), Professor Nat Lenzo said, "I'm excited to commence this important study that builds on the momentum of ProstACT SELECT. With previous studies having confirmed the preliminary efficacy and safety profile of TLX591, GenesisCare is pleased to partner with Telix to further their therapeutic antibody-based program, which has potential to improve health outcomes for thousands of men living with prostate cancer in Australia and worldwide."
Telix Chief Medical Officer Dr. Colin Hayward added, "Enrolling a first patient in the ProstACT TARGET study is a significant milestone in Telix's overall clinical mission to support men with prostate cancer at every step in their journey with a PSMA antibody approach to targeted radiation therapy. Alongside ProstACT SELECT, this program will add value and clinical insight to Telix's antibody therapy candidate TLX591, as we progress global regulatory submissions for the ProstACT GLOBAL Phase III study. We wish to express our gratitude to Professor Nat Lenzo and his clinical team, as well as the patients who will contribute to the study."
ProstACT is a series of studies of the investigational product TLX591, the Company's antibody-based, PSMA targeted prostate cancer therapy candidate TLX591 ( Lu-DOTA-rosopatamab).
The three studies running concurrently in the program are:
sites in Australia and New Zealand are being prepared to commence patient screening, ahead of initiating global sites.
first cohort of patients dosed.
patient enrolment has commenced.
Telix is a biopharmaceutical company focused on the development and commercialisation of diagnostic and therapeutic radiopharmaceuticals. Telix is headquartered in Melbourne, Australia with international operations in the United States , Europe ( Belgium and Switzerland ), and Japan . Telix is developing a portfolio of clinical-stage products that aims to address significant unmet medical need in oncology and rare diseases. Telix is listed on the Australian Securities Exchange (ASX: TLX). For more information visit www.telixpharma.com and follow Telix on Twitter (@TelixPharma) and LinkedIn.
Telix's lead product, gallium-68 ( Ga) gozetotide (also known as Ga PSMA-11) injection, has been approved by the U.S. Food and Drug Administration (FDA), and by the Australian Therapeutic Goods Administration (TGA). Telix is also progressing marketing authorisation applications for this investigational candidate in Europe and
Canada .
Headquartered in Sydney, Australia , GenesisCare is a global healthcare company and one of the world's largest integrated oncology organisations. The company's purpose is to design care experiences that get the best possible life outcomes. This is grounded in the belief that care should be focused on the individual, not the condition.
GenesisCare is the world's largest provider of radiotherapy – a vital treatment option for cancer patients – and provides patients with access to diagnostics, medical oncology, surgical oncology, radiotherapy, and novel therapies alongside the ability to participate in the latest clinical trials. With a growing research and trials program numbering more than 150 clinical trials, a contract research organisation, and global innovation programs focused on precision medicine and novel therapies, GenesisCare aims to bring new therapies to more patients in need in a more affordable way.
Every year, GenesisCare clinical teams see more than 400,000 people across 440+ locations, including more than 300 locations in the U.S., 40 in Australia , 14 in the UK, and 17 in Spain . A further 30 new centres are also under development. The organisation employs more than 6,000 highly trained physicians, healthcare professionals and support staff across Australia , Europe , and the U.S. For more information, visit www.genesiscare.com
Ms. Kyahn Williamson
Telix Pharmaceuticals Limited
SVP Corporate Communications and Investor Relations
Email: kyahn.williamson@telixpharma.com
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