Scienza e Tecnologia
Biocytogen Subsidiary, Eucure Biopharma, Announces the First Patient Dosing for a Phase I Multi-regional Clinical Trial of YH002 (Anti-OX40 mAb) in Combination with YH001 (Anti-CTLA-4 mAb) in Australia
Eucure Biopharma has previously completed mono-dose-escalation studies for YH001 and YH002. The results show that both YH001 and YH002 have good tolerance and safety.
Dr. Yuelei Shen, Chairman and CEO of Biocytogen and Eucure Biopharma, said, "Both YH001 and YH002 are developed from Biocytogen's evidence-based efficacy screening platform. Using animal models, we found for the first time, that combination of YH002 and YH001 has very good antitumor activity. We expect the results from animal models can be verified in patients. We are hopeful that these platforms will continue to drive the discovery and development of novel therapeutic antibodies, ADCs and bispecific ADCs for future clinical benefit."
YH002 is a recombinant anti-OX40 humanized IgG1 antibody. Targeting OX40 enhances anti-tumor responses both by activating effector T cells and inhibiting or exhausting regulatory T cells (Treg). In preclinical studies, YH002 demonstrated excellent specificity, affinity and safety. studies using Biocytogen's humanized mouse models demonstrated improved therapeutic potential of YH002 compared to benchmark antibodies, and indicated promising potential for combination therapy.
YH001 is an anti-CTLA-4 monoclonal antibody that aims to enhance the anti-tumor immune response through removal of Treg from the tumor microenvironment. Combination therapies that block multiple inhibitory immune checkpoints (including CTLA-4 and PD-1) are currently considered to be promising treatments for multiple types of tumors, due to their potential to influence the activity of multiple populations of T cells.
As a wholly owned subsidiary of Biocytogen, Eucure Biopharma is responsible for clinical development of Biocytogen's R&D pipelines, focusing on antibody drug therapy for oncology and other indications. Eucure's strong clinical development team has established an innovative product pipeline for more than 10 targets. Currently, two products have launched phase II MRCTs, and two are in phase I clinical trials.
Biocytogen Pharmaceuticals ( Beijing ) Co., Ltd. is a global biotechnology company that drives the research and development of new drugs with innovative technologies. Using RenMab and RenLite mice for fully human antibody production, Biocytogen has integrated its monoclonal and bispecific antibody development platforms, drug efficacy screening platforms and strong clinical development ability to streamline the entire drug development process. Biocytogen is undertaking a large-scale project to develop antibody drugs in collaboration with global partners for more than 1000 druggable targets, known as Project Integrum (also called RenMice HiTS Platform). With the implementation of Project Integrum, Biocytogen has initiated collaborations with dozens of partners worldwide, and will continue such collaborations to produce a variety of many first-in-class and/or best-in-class antibody drugs to benefit patients. Headquartered in Beijing , Biocytogen has branches in Haimen Jiangsu, Shanghai , and Boston , USA .
Media Contact:
Jenna Frame
Jframe@biocytogen.com
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