DEBIOPHARM SHARES ONCOLOGY PROGRAM UPDATES AT ASCO 2023 FOR NOVEL WEE1 INHIBITOR, AND FIRST-IN-CLASS CA IX THERANOSTIC APPROACH

"Both compounds are proposing innovative ways to tailor oncology treatments to patients. The theranostic pair Debio 0228/0328 aims to identify and benefit patients with CA IX-expressing tumors, starting with advanced ccRCC, PDAC and CRC. On the other hand, Debio 0123 continues to confirm its best-in-class potential in combination with carboplatin to overcome treatment resistance in solid tumors" expressed Dr. Angela Zubel, Chief Development Officer at Debiopharm. "Both compounds are proposing...

"Both compounds are proposing innovative ways to tailor oncology treatments to patients. The theranostic pair Debio 0228/0328 aims to identify and benefit patients with CA IX-expressing tumors, starting with advanced ccRCC, PDAC and CRC. On the other hand, Debio 0123 continues to confirm its best-in-class potential in combination with carboplatin to overcome treatment resistance in solid tumors" expressed Dr. Angela Zubel, Chief Development Officer at Debiopharm.

Poster Board #:
210, Hall A 

Location: S100bc

Poster Board #:
354b, Hall A

About Debio 0123 

Debio 0123 is a WEE1 kinase inhibitor. WEE1 is a catalyzing enzyme implicated in the G2/M and S phases. Activated in response to DNA damage, WEE1 allows cells to repair their DNA before resuming their cell cycle. By inhibiting WEE1, particularly in combination with other DNA damaging agents, the cell cycle checkpoints are compromised, driving cancer cells to start mitosis prematurely, or before the repair of detrimental DNA damage, promoting mitotic catastrophe and inducing apoptosis of cancer cells.

About Debio 0228/0328

The theranostic pair is formed of a first-in-class CA IX peptide-based (DPI-4452) radioligand therapy (lutetium-labelled [¹⁷⁷Lu]Lu-DPI-4452 or Debio 0228) combined with a PET imaging agent (gallium-labelled [⁶⁸Ga]Ga-DPI-4452 or Debio 0328). This theranostic pair, originally discovered by 3B Pharmaceutical GmbH and exclusively licensed to Debiopharm, utilizes Debio 0328 to identify patients whose cancers overexpress CA IX. Once identified, patients can be treated with the lutetium-labelled radioligand, Debio 0228, which delivers targeted radiation to the tumor, destroying it from the inside.

Debiopharm's commitment to patients  

Debiopharm develops innovative therapies that target high unmet medical needs in oncology and infectious diseases. Bridging the gap between disruptive discovery products and international patient reach, we identify high-potential compounds and technologies for in-licensing, clinically demonstrate their safety and efficacy and then select large pharmaceutical commercialization partners to maximize patient access globally. 

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Debiopharm Contact 
Dawn Bonine – Head of Communications 
dawn.bonine@debiopharm.com 
Tel: +41 (0)21 321 01 11

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