First-Ever Multicenter Study of Hypothermic Oxygenated Perfusion (HOPE) with VitaSmart™ in Pediatric Liver Transplants Confirms Safety and Favorable Outcomes

Conducted across five European pediatric liver transplant centers, results demonstrated that HOPE improves graft preservation by reducing reliance on static cold storage (liver preservation on ice alone) and mitigating ischemia-reperfusion injury, a serious complication that can compromise graft function. Importantly, the authors concluded that HOPE is safe in pediatric liver transplantation and is particularly beneficial for grafts with prolonged ischemia, including those from Donation after Circulatory Death (DCD) donors.

Conducted across five European pediatric liver transplant centers, results demonstrated that HOPE improves graft preservation by reducing reliance on static cold storage (liver preservation on ice alone) and mitigating ischemia-reperfusion injury, a serious complication that can compromise graft function. Importantly, the authors concluded that HOPE is safe in pediatric liver transplantation and is particularly beneficial for grafts with prolonged ischemia, including those from Donation after Circulatory Death (DCD) donors.

"These results highlight the first-ever multicenter study in this critical pediatric population of our VitaSmart™ HOPE System, and its safety in the pediatric population," said Don Webber, CEO and President of Bridge to Life Ltd., a global leader in transplant solutions and sponsor of the pivotal Bridge to Hope clinical trial. "By extending preservation time and protecting vulnerable grafts, this technology can increase the number of viable organs available for children awaiting transplantation—helping to reduce waiting times and save more lives."

About Bridge to Life™ Ltd

Bridge to Life™ Ltd is a market leader in organ preservation solutions, offering premier products such as Belzer UW®, EasiSlush®, and the VitaSmart™ Hypothermic Oxygenated Perfusion System. With a strong focus on product quality, innovation, and accessibility, the company partners with leading Transplant Centers and Organ Procurement Organizations worldwide.

VitaSmart™ is CE Marked and available for sale in several markets outside of the United States. VitaSmart™ is pending FDA clearance in the United States.

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