Scienza e Tecnologia
CARB-X Funds the 3rd Round of Debiopharm's Targeted Antibiotic Program to Combat Resistant N. gonorrhoeae Infections
Due to an alarming level of antimicrobial resistance and infection, represents a concerning global public health issue with a high unmet need for new treatments. In response to this urgent need, Debiopharm is developing Debio 1453, a novel narrow-spectrum antibiotic that inhibits FabI, an enzyme essential for fatty acid synthesis in this bacteria. A promising lead compound has emerged from previous development exhibiting strong efficacy in pre-clinical models. This compound has the potential to expand the range of treatments against and to be active against resistant strains.
"We are thrilled and appreciative having been awarded an additional grant from CARB-X. This renewal of research funding demonstrates the promising capacity of our antibiotic program to make a revolutionary impact in the battle against drug-resistant ," said Thierry Mauvernay, President of Debiopharm.
Various formerly efficacious treatments have become ineffective attributable to extensive history of microbial drug resistance. According to the CDC, it is paramount to perpetually observe antibiotic resistance in as well as stimulate the research and development of new treatment practices. The infection is transmitted to approximately 78 million people each year and can cause serious conditions such as pelvic inflammatory disease and in some cases, infertility in the absence of treatment.
"It is critical to act quickly in face of the skyrocketing amount of super-bugs indicating resistance to available antibiotics," said Bertrand Ducrey, CEO of Debiopharm. "In order for us to be equipped to evade an approaching epidemic of patients with vastly resistant to current therapies, we must continue to make strides in new treatment development."
Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) is an international not-for-profit partnership whose mission is to hasten antibacterial research to confront the worldwide emerging hazard of drug-resistant bacteria. CARB-X finances the leading scientific innovators across the globe, with up to $480 million to invest in from 2016 to 2022. Its portfolio includes the largest preliminary development pipeline of novel antibiotics, vaccines, rapid diagnostics and other preventative and diagnostic products in the world. Headquartered at the Boston University School of Law, the organization is led by Boston University and is funded by the US Department of Health and Human Services Biomedical Advanced Research and Development Authority (BARDA), a branch of the Office of the Assistant Secretary for Preparedness and Response, the Wellcome Trust, Germany's Federal Ministry of Education and Research (BMBF), the UK Government's Global Antimicrobial Resistance Innovation Fund (UK GAMRIF), the Bill & Melinda Gates Foundation, and receives in-kind support from National Institute of Allergy and Infectious Diseases (NIAID), part of the US National Institutes of Health (NIH).
Debiopharm develops & manufactures innovative therapies and drug delivery technologies that target high unmet medical needs in oncology and infectious diseases. Bridging the gap between disruptive discovery products and real-world patient reach, we identify high-potential compounds and technologies for in-licensing, clinically demonstrate their safety and efficacy and then select large pharmaceutical commercialization partners to maximize patient access globally.
For more information, please visit www.debiopharm.com
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Dawn Bonine
Communication Manager
dawn.bonine@debiopharm.com
Tel: +41 (0)21 321 01 11