Scienza e Tecnologia
Cancer vaccine biotech CimCure raises € 5 million in seed round investment led by Positron Ventures
CimCure was founded in 2016 as a spin-off of Amsterdam UMC supported by Amsterdam UMC's TTO Innovation Exchange Amsterdam and is led by Prof. dr. Arjan Griffioen , CSO, and Diederik Engbersen , CEO. Both have extensive experience in the biotech industry and started CimCure to commercialise a smart, effective and safe treatment strategy against all types of solid tumors at all stages, and can be combined with conventional and state-of-the-art anti-cancer strategies.
CimCure develops cancer vaccines through its proprietary Immune-Boost (iBoost) technology of targeted conjugate vaccines. The company has identified specific targets in the tumor vasculature. Eradication of tumor blood vessels and inhibition of their growth will lead to inhibition of cancer growth. This is an attractive approach for treatment of cancer. However, past and current angiostatic drugs are known for rapid induction of drug resistance and loss of effectiveness, due to intervention in tumor-produced growth factors or their receptors. CimCure's approach directly targets the tumor blood vessels, which efficiently attenuates tumor growth directly and does not induce resistance. An additional advantage of targeting blood vessels is that the barrier function of the tumor vasculature for leukocytes can be overcome (Huinen et al, Nature Reviews Clinical Oncology, 2021).
CimCure is a 2016 spin-off from Amsterdam UMC. CimCure focuses on the design and development of a novel class of active cancer immunotherapies. The company is privately funded and maintains a web presence at www.cimcure.com.
Positron Ventures is a € 75m (pre-)seed fund for European science startups that tackle the world's biggest challenges and can benefit from operational involvement by our team of entrepreneurs, dealmakers and teambuilders.
See for more info: www.positron.ventures
IXA is a network, servicedesk and liaison organization for Amsterdam UMC, offering researchers the expertise of grant advisers, business developers and legal experts to help determine a valorisation/ impact strategy. IXA assists in setting up collaborations with third parties and/or starting new ventures, while managing intellectual property and other legal and financial support.
For more information, please visit www.ixa.nl
Diederik Engbersen , CEO
T: +31 6 46 336 338
E: djm.engbersen@cimcure .com
Joseph Peeraer , founding partner
T: +31 6 51 197 847
E: joseph@positron.vc
Daniëla Cohen, press officer Amsterdam UMC
T: +31 20 444 3444
E: d.cohen@amsterdamumc.nl
LifeSpring Life Sciences Communication, Amsterdam, the Netherlands
Leon Melens
T: +31 6 538 16 427
E: lmelens@lifespring.nl
Huinen, Z., Huijbers, E.J.M., Van Beijnum, J.R., Nowak-Sliwinska, P., and Griffioen, A.W. (2021). Anti-angiogenic agents - overcoming tumor endothelial cell anergy and improving immunotherapy outcomes. Nat. Rev. Clin. Oncol. 18, 527-540.
Van Beijnum, J.R., Huijbers, E.J.M., Van Loon, K., Blanas, A., Akbari, P., Roos, A., Wong, T.J., Denisov, S., Jimenez, C.R., Hackeng, T.M., (2022). Extracellular vimentin mimics VEGF and is a target for anti-angiogenic immunotherapy Nat Commun 13, 20.
Logo - https://mma.prnewswire.com/media/1833632/CimCure_logo_1_Logo.jpg