Salute e Benessere
Adcendo ApS Announces First Patient Dosed in Phase I/II ADCElerate1 Trial of ADCE-D01
Dr. Lone Ottesen , Chief Medical Officer of Adcendo, said: "The dosing of the first patient in the ADCElerate1 study is a major milestone for both Adcendo and for the uPARAP program and we are excited to evaluate ADCE-D01's potential benefit for patients with advanced STS. uPARAP is a highly attractive target for the development of an ADC in mesenchymal cancers, as it is highly overexpressed in multiple STS subtypes, has unique internalization properties, and shows only very low expression in healthy tissues."
Professor Robert Maki , MD, PhD, Sarcoma Oncologist and Early Drug Development Specialist at the Department Musculoskeletal Cancers and Condition, in the Memorial Sloan Kettering Cancer Center, New York, NY , commented: "We are very pleased to be working with Adcendo to develop ADCE-D01 for the many advanced STS patients who currently have very limited treatment options. ADCs have already made a significant impact across the therapeutic landscape, and we are pleased to be able to bring this exciting treatment modality to our sarcoma patients."
ADCE-D01 is an antibody-drug conjugate (ADC) targeting the uPARAP receptor. uPARAP is a continuously recycling endocytic receptor involved in collagen homeostasis. uPARAP exhibits a restricted expression profile in healthy tissues but is highly upregulated in multiple mesenchymal cancers, including STS, bone sarcoma, GIST, as well as mesothelioma and glioblastoma. ADCE-D01 is a first-in-class pan-mesenchymal cancer targeting ADC in phase 1/2 clinical development.
Adcendo is a clinical-stage biotechnology company headquartered in Copenhagen, Denmark , with operations in Boston, Massachusetts . The company is developing a pipeline of first-in-class antibody-drug conjugates (ADCs) targeting cancers with high unmet medical needs. Led by a team of industry veterans with a track record of advancing multiple ADCs to approval, Adcendo integrates novel targets, optimized linker-payload combinations, and a rationally designed development strategy to drive next-generation cancer therapies. For further information, please visit www.adcendo.com or follow the company on LinkedIn.
Logo - https://mma.prnewswire.com/media/2565778/Adcendo_Logo_Logo.jpg
View original content:https://www.prnewswire.co.uk/news-releases/adcendo-aps-announces-first-patient-dosed-in-phase-iii-adcelerate1-trial-of-adce-d01-302475077.html