Salute e Benessere
Alchemab Therapeutics initiates Phase 1 clinical trial of ATLX-1282 and announces Series A financing extension
Alchemab's proprietary, AI-enabled platform is transforming drug discovery by identifying protective auto-antibodies and novel targets from individuals that are naturally resilient to various diseases. The platform operates like a search engine for the immune system, leveraging advanced machine learning models and proprietary data to interrogate the largest database of patient-derived antibodies, known as the DataCube, comprising over 6,000 highly curated patient samples from more than 30 global collaborators across metabolic, immune and neurological conditions.
The additional capital will enable Alchemab to advance ATLX-2847, a wholly-owned program for muscle atrophy derived from the platform, into clinical development. ATLX-2847 is a first-in-class program targeting the prostaglandin pathway. The financing will also support Alchemab to advance highly novel earlier programs for immune and neurological conditions towards clinic, and further expand its AI-enabled, disease resilience-led platform.
This financing follows a separate research collaboration with Lilly announced in January 2025 for the discovery, development and commercialisation of up to five novel therapeutic candidates for neurodegenerative disease.
"As a founding investor in Alchemab, we are thrilled to close this financing and initiate clinical development, which together mark a very successful year for Alchemab and the Company's novel platform to identify protective auto-antibodies," . "We're extremely pleased to welcome new investors who share our commitment to novel drug discovery and development approaches and are proud to support Alchemab's continued progress."
"Reaching the key milestone of our first drug candidate into the clinic is great validation of Alchemab and our AI enabled next generation antibody platform. Through our collaboration with Lilly, we hope to get this, our first clinical candidate and a potentially transformative therapy, to as many patients as possible, as quickly as possible."
"I am excited about the rapid progress we have made with this candidate as part of a joint team effort with Alchemab and look forward to seeing its performance in the clinic."
Alchemab studies the natural antibody responses of individuals who are highly resilient to disease and identifies antibodies uniquely shared in the resilient groups and not seen in disease progressors. The targets to these antibodies are then identified and the antibodies developed into therapies for hard-to-treat diseases which do not have disease modifying approaches. Alchemab's platform integrates data mining and machine learning models of patient-derived immune responses with in vitro and in vivo drug discovery approaches to understand what keeps people well. The goal is to unlock nature's immunological response to disease and harness our highly evolved human immune system to find breakthrough drugs. Alchemab was founded in 2019 and is headquartered in London, UK with labs in Cambridge , UK.
For more information, visit www.alchemab.com.
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