Scienza e Tecnologia
Nagase R&D Center Increases Productivity of Rare Amino Acid "Ergothioneine" 1000-fold: Highest Production Efficiency Reported Using "Smart Cell" Technology
(Image: https://kyodonewsprwire.jp/prwfile/release/M105348/202010025256/_prw_PI2fl_CU962Wf6.jpg)
EGT is a natural amino acid found in trace amounts in mushrooms and other organisms, with excellent antioxidant properties and potential applications in a variety of fields, including food products, cosmetics, and medicine. Current EGT production methods include extracting natural EGT and chemical synthesis, but either require high cost or cause environmental concerns, therefore preventing the widespread adoption of EGT.
The Nagase R&D Center's technology could provide a stable supply EGT through a sustainable fermentation process using microorganisms. Four Smart Cell foundational technologies (enzyme design, metabolic pathway design, HTP microorganism construction/evaluation, transporter identification) were applied to improve EGT productivity by optimizing production reaction within microorganism cells. As a result, an exponential improvement in production became possible.
By using cutting-edge biotechnology, the Nagase R&D Center will provide products with high added value through sustainable processes and contribute to the creation of "a sustainable world where people live with peace of mind."
Notes:
(*1) EGT: A natural amino acid produced only by some organisms, such as mushrooms. Research in recent years has shown that humans have systems in place to utilize EGT. It has been suggested that EGT ingested through food may help improve brain function and protect cells in the skin, eyes, and various organs from oxidative stress. (NAGASE article on Nature website URL: https://www.nature.com/articles/d42473-020-00227-4)
L-ergothioneine: https://kyodonewsprwire.jp/img/202010025256-O3-Ltcb7ZlJ
(*2) According to investigation by the Nagase R&D Center.
Official website: https://www.nagase.co.jp/english