Scienza e Tecnologia
Enesi Pharma's ImplaVax®-Enabled, Solid-Dose Modified Live Virus Vaccine Produces Neutralising Antibody and T-Cell Responses Equivalent to Liquid Vaccine Delivered via Needle and Syringe
OXFORD, England , Sept. 29, 2020 /PRNewswire/ -- Enesi Pharma ("Enesi"), an innovative biotechnology company developing next-generation vaccination products targeting infectious diseases and emergent threat pathogens enabled by its ImplaVax® technologies, is delighted to report positive top-line results from a new study evaluating the immune responses generated by an ImplaVax®-enabled unit solid-dose formulation of a live attenuated porcine reproductive and respiratory syndrome virus (PRRSV) vaccine. The study was conducted in collaboration with The Pirbright Institute, a UK-based global centre of excellence in research and surveillance of viral diseases of livestock and viruses that spread from animals to humans.
The study confirmed the utility of ImplaVax® to create a solid-dose live virus vaccine that is immunogenic with the potential for enhanced thermal stability. The subcutaneously delivered ImplaVax® format generated both neutralising antibodies and T-cell responses comparable to the standard liquid vaccine delivered either subcutaneously or intramuscularly via needle and syringe.
PRRSV infects domestic pigs and causes porcine reproductive and respiratory syndrome, which is highly infectious and is characterised by clinical signs such as reproductive failure, fever, respiratory difficulties, and increased mortality. PRRSV is found in most areas of the world where pigs are raised and is one of the most economically important diseases for the global pig industry, with losses estimated to exceed $664 million annually in the USA alone .
More details of the study and its results will be presented in an upcoming publication.
Holtkamp D.J., . 2013;21(2):72-84
https://www.fortunebusinessinsights.com/industry-reports/veterinary-animal-vaccines-market-101532
Enesi Pharma is developing next-generation vaccination products targeting infectious diseases and emergent threat pathogens enabled by its ImplaVax® technologies. These diseases affect millions of people around the world. We work in partnership with global companies, government agencies, leading academic institutions and non-governmental organisations with the goal of making a material and lasting positive impact on global health.
Our ImplaVax®-enabled vaccination products leverage our innovative unit solid-dose formulation and needle-free delivery technologies and are applicable across all vaccine formats. ImplaVax® products are designed to enhance the immune response and offer significant benefits for patients, care givers, healthcare professionals and payers through enhanced effectiveness, safety, ease of use, reliability and stability, and a strong subject preference over administration using needle and syringe. They can be administered with minimal training and are also rapidly deployable while eliminating the need for cold-chain storage.
Our pipeline targets a range of common and emerging infectious diseases, inflammatory diseases and allergies, and has been established through collaborations with world-class organisations, including BARDA DRIVe*, the Bill & Melinda Gates Foundation, Innovate UK, the University of Oxford , the Walter Reed Army Institute of Research (WRAIR), Sementis and the University of Adelaide. Our collaboration with Pirbright is one of a number of developing collaborations in animal health.
Enesi's experienced leadership team has a proven track record in the successful development and commercialisation of innovative products delivering high value outcomes for all stakeholders and is supported by a world-renowned Scientific Advisory Board.
The Pirbright Institute is a world leading centre of excellence in research and surveillance of virus diseases of farm animals and viruses that spread from animals to humans. Based in the UK and receiving strategic funding from the Biotechnology and Biological Sciences Research Council (BBSRC) part of UK Research and Innovation (UKRI), the Institute works to enhance capability to contain, control and eliminate these economically and medically important diseases through highly innovative fundamental and applied bioscience.
The Institute is an independent company, limited by guarantee and a registered charity, governed by a Board of non-executive Trustee Directors.
With an annual income of £35 million from grants and commercial activity, and a total of £25.2 million strategic investment from BBSRC UKRI during 2019-2020, the Institute contributes to global food security and health, improving quality of life for animals and people.
For more information about The Pirbright Institute see: www.pirbright.ac.uk
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David Hipkiss , CEO
Tel: +44 (0) 7968 707072
Email: david.hipkiss@enesipharma.com
Mark Swallow , Nathaniel Dahan
Tel: +44 (0) 20 7638 9571
Email: enesipharma@citigatedewerogerson.com
Kimberley Stirk
Tel: +44 (0) 1483 231120
Email: communications@pirbright.ac.uk
Web www.enesipharma.com | LinkedIn @EnesiPharma | Twitter @Enesi_Pharma