Salute e Benessere
deCODE genetics: Complete recombination map of the human-genome, a major step in genetics
While this shuffling, known as recombination, is essential for genetic diversity, errors in the process can lead to serious reproductive issues. These failures can result in genetic errors that prevent pregnancies from continuing, helping to explain why infertility affects around one in ten couples worldwide. Understanding this process offers new hope for improving fertility treatments and diagnosing pregnancy complications.
The research also reveals key differences between men and women in how and where, the genome recombination occurs. Women have fewer non-crossover recombinatios, but their frequency increases with age, which may help explain why older maternal age is associated with higher risks of pregnancy complications and chromosomal disorders of the child. Men, however, do not show this age-related change, although recombination in both sexes can contribute to mutations passed to offspring.
Understanding the recombination process is also important in understanding how humans evolved as a species and what shapes individual differences, including health outcomes. All human genetic diversity can be traced to recombination and de novo mutations, DNA sequence present in the child but not in the parents. The map shows that mutations are elevated near regions of DNA mixing and consequently that the two processes are highly correlated.
Video - https://mma.prnewswire.com/media/2600841/Kari_and_Bjarni.mp4
Photo - https://mma.prnewswire.com/media/2600840/Kari_Gunnar_Bjarni.jpg
Logo - https://mma.prnewswire.com/media/1535464/deCODE_genetics_Amgen_Logo.jpg
View original content:https://www.prnewswire.co.uk/news-releases/decode-genetics-complete-recombination-map-of-the-human-genome-a-major-step-in-genetics-302354565.html