A Hypercompact CRISPR Technology Developed by GenKOre is deemed a Potential Game Changer in Gene Therapy

Because the size of the gene in the 'CRISPR/Cas12f-GE' system developed by GenKOre is one-third that of Cas9, it is an ideal payload for AAV delivery. GenKOre demonstrated its potential utility as the best gene therapy by improving the editing efficiency. In addition to high editing efficiency, it has proven to be effective and safe as gene scissor technology with respect to the off-target issue, a chronic weakness of CRISPR gene scissors. Because the size of the gene in the 'CRISPR/Cas12f-GE'...

South Korea, 20/10/2021 (informazione.news - comunicati stampa - scienza e tecnologia)

Because the size of the gene in the 'CRISPR/Cas12f-GE' system developed by GenKOre is one-third that of Cas9, it is an ideal payload for AAV delivery. GenKOre demonstrated its potential utility as the best gene therapy by improving the editing efficiency. In addition to high editing efficiency, it has proven to be effective and safe as gene scissor technology with respect to the off-target issue, a chronic weakness of CRISPR gene scissors.

The hypercompact CRISPR system Cas12f-GE has revealed its value as a therapeutic agent that can be widely used for developing medical treatments for patients who chronically suffer from life-long illnesses or diseases due to the lack of fundamental remedies.

GenKOre, which successfully developed this new technology, is a spin-off company of the Korea Research Institute of Bioscience & Biotechnology (KRIBB), a research institute funded by the South Korean government.

Dr. Yong-Sam Kim , CEO of GenKOre remarked, "I hope that our achievements based on our research will bring about a revolution in gene therapies utilizing this genome-editing tool. Our technology can be seen as a breakthrough by resolving the major obstacle linked to the original CRISPR technology, and I am optimistic that in tandem with existing gene scissors, our technology will contribute to the human health and welfare."

With the successful development of CRISPR/Cas12f-GE, GenKOre plans to step up its development of gene therapy and new products through its unique gene scissor technology and collaborate with other companies in becoming a market leader in the realm of gene therapy and new plant biotechnology.

For more content on GenKOre's paper published online by Nature Biotechnology, refer to https://www.nature.com/articles/s41587-021-01009-z.

The website of GenKOre is www.genkore.com

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