Novel biologic Ab-IPL-IL-17™ shows promise for rheumatoid arthritis and inflammatory bowel disease

The antibody, called Ab-IPL-IL-17™, targets a specific section of signalling proteins IL-17A and IL-17F which play a central role in sustaining inflammation during onset and progression of autoimmune diseases. The antibody, called Ab-IPL-IL-17™, targets a specific section of signalling proteins IL-17A and IL-17F which play a central role in sustaining inflammation during onset and progression of autoimmune diseases. A paper published today in theAnnals of Rheumatic Diseases  identifies the...

The antibody, called Ab-IPL-IL-17™, targets a specific section of signalling proteins IL-17A and IL-17F which play a central role in sustaining inflammation during onset and progression of autoimmune diseases.

A paper published today in the Annals of Rheumatic Diseases identifies the sequence, and reports the results of animal, cell and tissue studies that demonstrate the effectiveness of Ab-IPL-IL-17™, and its potential clinical benefit for people with RA and IBD.

Authored by Dr Asif Iqbal from the University of Birmingham and Professor Francesco Maione, Head of ImmunoPharma Lab from the University of Naples Federico II, the paper reports studies which showed:

A patent application has been filed covering the antibody and its therapeutic use.  The researchers are seeking commercial partners willing to conduct a large-scale clinical evaluation of Ab-IPL-IL17™ in patients with immune-mediated inflammatory diseases (IMIDs). 

The research demonstrated a short sequence of IL-17A and IL-17F is the most biologically active sequence of IL-17, stimulating the release of cyto-chemokines (inflammatory molecules that generate and amplify inflammation), to the same extent as full-length IL-17, and driving immune cell migration to an even greater extent than the parent molecule. 

Animal studies comparing Ab-IPL-IL-17™ to existing anti-IL-17 therapies (secukinumab, ixekizumab and bimekizumab) showed it does not trigger unwanted immune responses, reduce the numbers of platelets, or increase the numbers of lymphocytes (white blood cells) in the blood. 

For commercial enquiries contact Dr Veemal Bhowruth at University of Birmingham Enterprise.

The University of Birmingham is ranked amongst the world's top 100 institutions, and its work brings people from across the world to Birmingham, including researchers and teachers and more than 6,500 international students from nearly 150 countries.

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