Salute e Benessere
Novo Nordisk's CagriSema was associated with significant reduction in blood pressure and showed anti-inflammatory effects while reducing the proportion of patients at risk of developing heart disease over time in new analyses at ObesityWeek®
"We're very excited by the results of these analyses of CagriSema, which show promising results of combining cagrilintide with the proven significant effects of semaglutide on CV health," said Martin Holst Lange , chief scientific officer and executive vice president of Research & Development at Novo Nordisk. "People living with obesity have treatment goals that often include both losing weight and improving overall health. That's why we continue to explore new therapies that we hope will deliver on weight loss needs while reducing the risk of obesity-related health issues like cardiovascular disease."
CagriSema was also associated with a reduction in a key marker of body-wide inflammation – high-sensitivity C-reactive protein (hsCRP) – at week 68, regardless of baseline hsCRP levels. The reduction with CagriSema (–68.9%) was greater than with semaglutide 2.4 mg alone (–55.4%) or placebo (–16.0%). In a mediation analysis, the hsCRP reduction with CagriSema was only partially explained by weight loss, suggesting that the inflammatory effects of CagriSema are not fully weight loss dependent.
"The CagriSema data presented at ObesityWeek are very encouraging regarding the effects on well-known CV risk factors like high blood pressure – a strong signal that warrants further investigation. High blood pressure has a significant impact on the heart, increasing the risk of heart attacks and strokes and, alongside inflammation, is a key driver of cardiovascular disease," said Professor Subodh Verma , Cardiac Surgeon and Canada Research Chair Division of Cardiac Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto , Canada. "If we can lower inflammation, bring blood pressure to more normal levels, and help people lose weight at the same time, there's potential for holistic improvement in overall health."
High blood pressure and chronic inflammation are critical in the development of atherosclerotic cardiovascular disease (ASCVD). CagriSema reduced the proportion of people who were at intermediate-to-high risk of developing ASCVD within the next 10 years. A dedicated trial (REDEFINE 3) is ongoing to investigate the effect of CagriSema on CV outcomes in patients with established cardiovascular disease, with or without type 2 diabetes.
Safety data generated in the REDEFINE 1 trial were comparable with the GLP-1 RA class. Overall, discontinuation rates due to adverse events were low, with 6% for CagriSema versus 3.7% for placebo. In REDEFINE 1, adverse events were mainly gastrointestinal (79.6% in the CagriSema group versus 39.9% with placebo), including nausea (55% versus 12.6%), constipation (30.7% versus 11.6%), and vomiting (26.1% versus 4.1%), and were mostly transient and mild-to-moderate in severity.
Based on the trial product estimand; estimated treatment effect if all participants adhered to treatment.
CagriSema is being investigated by Novo Nordisk as a once-weekly subcutaneous injectable treatment for adults with overweight or obesity (REDEFINE program) and as a treatment for adults with type 2 diabetes (REIMAGINE program). CagriSema is a fixed-dose combination of a long-acting amylin analogue, cagrilintide 2.4 mg, and the GLP-1 receptor agonist, semaglutide 2.4 mg.
CagriSema is not approved in the US or EU.
REDEFINE 1 was a double-blind, placebo-and active-controlled 68-week efficacy and safety phase 3 trial of once-weekly CagriSema (cagrilintide 2.4 mg and semaglutide 2.4 mg), cagrilintide 2.4 mg monotherapy and semaglutide 2.4 mg monotherapy versus placebo in 3,417 adults with obesity (BMI ≥30 kg/m ), or overweight (BMI ≥27 kg/m ) with one or more obesity-related comorbidities, and without type 2 diabetes.
Obesity is a serious chronic, progressive and complex disease that requires long-term management. One key misunderstanding is that this is a disease of just lack of willpower, when in fact there is underlying biology that may impede people with obesity from losing weight and keeping it off. Obesity is influenced by a variety of factors, including genetics, social determinants of health, and the environment.
mxun@novonordisk.com
_______________________
© 2025 Novo Nordisk All rights reserved. US25SEMO03075 October 2025
Logo - https://mma.prnewswire.com/media/466582/Novo_Nordisk_Logo.jpg
View original content:https://www.prnewswire.co.uk/news-releases/novo-nordisks-cagrisema-was-associated-with-significant-reduction-in-blood-pressure-and-showed-anti-inflammatory-effects-while-reducing-the-proportion-of-patients-at-risk-of-developing-heart-disease-over-time-in-new-analyses-at-o-302607645.html