Salute e Benessere
India's No: 1 Ranked Institute, IIT Madras & Danish University Study reveals Genetic 'Switches' that can transform Disease Research
In this study, the researchers, using systems-level multi-omic approaches, showed how genetic variants in yeast work together to activate previously dormant metabolic pathways. By revealing how these gene–gene interactions dynamically rewire metabolism, the study provides a powerful framework for decoding how multiple genes combine to modify and improve complex phenotypes.
The research was led by Mr. Srijith Sasikumar, a PhD student, and Prof. Himanshu Sinha , from the Department of Biotechnology, IIT Madras, in collaboration with Dr. Shannara Taylor Parkins and Dr. Suresh Sudarsan from the Technical University of Denmark .
The practical applications of this research include the development of biomarkers and the identification of drug targets that capture the combined effects of genetic variants, enabling more accurate disease diagnosis, prognosis, and the design of personalized treatment strategies tailored to an individual's unique genetic background. Beyond medicine, the framework may also find applications in industrial biotechnology, where rewiring metabolic pathways in microorganisms can be used to optimise biofuel production, and in enhancing agricultural research, to improve crop and animal yields.
Together, these applications highlight how a discovery in a simple organism like yeast can translate into far-reaching benefits for human health, industry, and society.
Photo: https://mma.prnewswire.com/media/2791473/IIT_MADRAS_Campus.jpg
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