Collaborators at the Keio and Osaka Universities Present Key Non-Clinical Data with Stable/Functional-Induced Regulatory T Cells (S/F-iTregs) in Autoimmune Disease Models

Tregs play a central role in managing immune self-tolerance and depleted or dysfunctional Tregs are characteristic of many autoimmune disorders. "There has been interest in using Tregs as a treatment for autoimmune disorders for many years.  However, to date, these efforts have been limited by lack of antigen-specificity and persistence. The ability to create stable/functional Treg cells that are antigen-specific has until now been elusive. We believe that RegCell's proprietary platform can accomplish this goal by inducing Tregs from antigen-specific effector T-cells that appear to maintain their functionality, and we look forward to advancing our S/F-iTreg platform into clinical development", said Professor Sakaguchi.

Tregs play a central role in managing immune self-tolerance and depleted or dysfunctional Tregs are characteristic of many autoimmune disorders. "There has been interest in using Tregs as a treatment for autoimmune disorders for many years.  However, to date, these efforts have been limited by lack of antigen-specificity and persistence. The ability to create stable/functional Treg cells that are antigen-specific has until now been elusive. We believe that RegCell's proprietary platform can accomplish this goal by inducing Tregs from antigen-specific effector T-cells that appear to maintain their functionality, and we look forward to advancing our S/F-iTreg platform into clinical development", said Professor Sakaguchi.

About RegCell

RegCell is a preclinical-stage biotechnology company located in Japan with investment from leading Japanese institutional investors including The University of Tokyo Edge Capital Partners.  RegCell is developing S/F-iTregs as a potential treatment for patients with autoimmune disorders and to prevent transplant rejection. 

For more information about RegCell please visit https://regcell.jp/en/

Contact: Daisuke Ishikawa, Ph.D. (hpregcell@regcell.jp)

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