Scienza e Tecnologia
Enterome's GeneMark-HM software highlighted as the most accurate microbiome gene prediction software in peer-reviewed publication NAR Genomics and Bioinformatics
GeneMark-HM is a computational pipeline (i.e. a chain of genomic information processing tools) specifically developed to enhance the reliability of Enterome's drug discovery platform and accelerate the discovery of novel candidates.
The publication showed that GeneMark-HM improves the accuracy of gene prediction in human microbiome metagenomic sequences in comparison with current state-of-art gene prediction tools. This improvement was clearly seen:
In an assessment of gene accuracy, outlined in the publication on benchmark metagenomic sequences, the GeneMark-HM pipeline showed the lowest rate of errors in gene recognition and the lowest percentage of incorrect starts compared to current state-of-the-art gene prediction tools.
Publication reference: GeneMark-HM: improving gene prediction in DNA sequences of human microbiome, A. Lomsadze and all, NAR Genomics and Bioinformatics, 2021 (1-11), doi: 10.1093/nargab/lqab047 - Link
Marine Perrier
Head of External Communications and Investor Relations
investorrelations@enterome.com
Sylvie Berrebi / Mark Swallow /
David Dible
Citigate Dewe Rogerson
Tel. +44 207 638 9571
Enterome is a clinical stage biopharmaceutical company developing novel drugs based on its unique ability to de-code molecular interactions in the gut microbiome impacting human health. Enterome's success is based on its unique ability to identify small proteins and peptides ("effectors") from gut bacteria that can deliver a therapeutic benefit in humans.
Enterome is leveraging this unique ability to develop two highly promising pipelines of clinical and pre-clinical candidates with a focus on cancer, inflammatory and metabolic diseases:
- : innovative, off-the-shelf, microbiome peptide powered cancer vaccines (EO2401, EO2463). EO2401 is in Phase 1/2 clinical trials in patients with glioblastoma and adrenal tumors. EO2463 is in a Phase 1/2 clinical trial for indolent non-Hodgkin B-cell lymphomas.
- : a new generation of biologics targeting inflammatory diseases (EM101) and metabolic diseases such as Type 2 diabetes.
These pipelines have been created using Enterome's highly efficient proprietary drug discovery platform that uses machine learning and lab assays to interrogate and decode the world's largest database of gut bacterial proteins, a unique source of novel precision drugs.
In addition, Enterome's clinical candidate Sibofimloc (also referred to as TAK-018) is advancing through Phase 2 clinical trials in Crohn's disease. Sibofimloc has been partnered with Takeda globally, with Enterome retaining a significant profit share in the US.
Enterome is headquartered in Paris (France) and is backed by leading venture capital investors.
For more information, please visit the company's website at: www.enterome.com