Salute e Benessere
MOBILion Systems to Present Transformative Advances in Proteomics Sensitivity and Throughput at HUPO 2025
As proteomics research increasingly emphasizes and as critical indicators in drug development and clinical diagnostics, technologies that enhance detection depth and confidence are reshaping how scientists interrogate biological complexity. MOBILion's PAMAF technology enables near-100% ion utilization and delivers industry-leading spectral generation rates exceeding 500Hz. This performance advancement can only be achieved via MOBILion's high-speed HRIM separation and reduces the reliance on the slow and lossy quadrupole filtering.
"In a field where incremental gains are often considered meaningful, PAMAF delivers improvements of 300–2,000% in fragment ion intensity boosting identification rates," said . "These advances will enable researchers to identify thousands more proteins and PTMs from smaller samples, opening new frontiers in proteomics, biomarker discovery, and therapeutic development."
DeBord's presentation will feature data from experiments coupling MOBILion's with an existing QTOF platform. The results demonstrate up to , , and , with even greater improvements at low sample inputs, MOBILion's PAMAF mode of operation will be transformative for and .
"These findings highlight improved ion utilization as a fundamental performance lever in mass spectrometry," said DeBord. "By eliminating quadrupole filtering and aligning fragmentation with ion mobility, PAMAF enables more comprehensive, unbiased analysis across complex biological samples, bringing us closer to complete proteome and proteoform coverage."
MOBILion Systems develops high-performance analytical instruments that reveal previously unseen molecular detail by integrating technology with high-resolution mass spectrometry. The company's proprietary High-Resolution Ion Mobility (HRIM) technology improves separation power, sensitivity, and throughput across proteomics, metabolomics, lipidomics, and clinical research applications. MOBILion's mission is to empower scientists to accelerate discovery, enhance precision medicine, and improve human health by .
Hannah Steele
The Scott Partnership
+44 1477 539 539
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