New study: ColdZyme breaks viral infection cycle - significantly reducing influenza viral load - Enzymatica AB

"We know from previous studies that ColdZyme blocks viruses from sticking. These new results, showing how ColdZyme breaks the infection cycle, could open new commercial opportunities for Enzymatica. We are expecting results from an in vivo study from the University of Kent within the coming month and anticipate that it will add further clinical insights", said Claus Egstrand, CEO of Enzymatica. The research group is working on a manuscript for publication, expected in 2023. It was decided to announce the outcome of the study in advance, since Enzymatica as a listed company is obliged to urgent disclosure of insider information. Further studies involving ColdZyme will be conducted in Innsbruck during the year. More about the studyHighly differentiated, mucus-producing, and ciliated primary human bronchial airway epithelial cells were infected with influenza A virus (H3N2) and incubated for 16 hours. The cells were then treated with ColdZyme, that was left on the cells for 20 minutes and…

"We know from previous studies that ColdZyme blocks viruses from sticking. These new results, showing how ColdZyme breaks the infection cycle, could open new commercial opportunities for Enzymatica. We are expecting results from an in vivo study from the University of Kent within the coming month and anticipate that it will add further clinical insights", said Claus Egstrand, CEO of Enzymatica.
 
The research group is working on a manuscript for publication, expected in 2023. It was decided to announce the outcome of the study in advance, since Enzymatica as a listed company is obliged to urgent disclosure of insider information. Further studies involving ColdZyme will be conducted in Innsbruck during the year.
 
More about the study
Highly differentiated, mucus-producing, and ciliated primary human bronchial airway epithelial cells were infected with influenza A virus (H3N2) and incubated for 16 hours. The cells were then treated with ColdZyme, that was left on the cells for 20 minutes and then removed to resemble duration of ColdZyme in the oral cavity. The viral load was determined in the liquid that was removed and in a sample taken from the basolateral side. Treatment and viral load analysis was repeated on day 2 and day 3 after infection. On day 3, the cells were analyzed to examine viability. As a positive control, influenza A infected cells were treated with salt solution instead of ColdZyme.
 
The research was conducted by the Wilflingseder research group of the Institute of Hygiene and Medical Microbiology at the Medical University of Innsbruck, Austria. Previous research on ColdZyme from the same research group includes: ColdZyme® protects airway epithelia from infection with BA.4/5 | Respiratory Research | Full Text (biomedcentral.com)

The information in this press release is information that Enzymatica is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out below, at 10:45 CET on August 22, 2023.

FOR MORE INFORMATION, PLEASE CONTACT:

Claus Egstrand, CEO, Enzymatica AB
Phone: +44 7780 22 8385 | Email: claus.egstrand@enzymatica.com

Stefan Olsson, Communication Manager, Enzymatica AB
Phone: +46 708 55 11 85 | Email: stefan.olsson@enzymatica.com

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