Salute e Benessere
PeproMene Bio's PMB-CT01 BAFFR-CAR T Data Selected for Two Oral Presentations at 67th ASH 2025 Annual Meeting
PMB-CT01 demonstrated an exceptionally favorable tolerability profile. No Grade ˃1 Cytokine Release Syndrome (CRS) and no Grade ˃1 Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS)
All the first 7 patients achieved a Complete Response (CR) at 1–3 months post-infusion, including those previously treated with CD19 CAR T therapy and those with CD19-negative disease.
Remissions have remained ongoing for up to 32+ months (median 17 months) at data cutoff.
Four of six enrolled patients achieved an undetectable Minimal Residual Disease (MRD-) Complete Remission (CR)
Three of the four responders were CD19-negative at enrollment. All three successfully transitioned to allogeneic hematopoietic cell transplant (HCT) with curative intent.
No Dose-Limiting Toxicities (DLTs) were observed. Only one patient experienced Grade 2 CRS, with no Grade 3 CRS reported.
"The consistent and durable activity seen across both B-ALL and B-NHL, particularly in patients who have exhausted CD19 CAR T options or present with CD19-negative disease, strongly supports BAFF-R as a highly effective and safe alternative target," said Hazel Cheng , Ph.D., COO of PeproMene Bio. "These data highlight PMB-CT01's potential to address critical unmet needs in high-risk relapsed disease."
abs25-7079 December 6 ,
2:45 PM Elizabeth Budde , M.D., Ph.D.
abs25-2035 December 8 , 11:00 AM Ibrahim Aldoss, M.D.
PMB-CT01 is a first-in-class BAFF-R–targeted autologous CAR T cell therapy. BAFF-R is expressed almost exclusively on B cells and is essential for B-cell survival, reducing the likelihood of antigen-loss escape. PMB-CT01 is being evaluated in Phase 1 trials for r/r B-NHL and r/r B-ALL.
This press release contains forward-looking statements subject to risks and uncertainties, including risks related to clinical development, regulatory outcomes, therapeutic potential, and commercialization. PeproMene Bio undertakes no obligation to update forward-looking statements except as required by law.
Hazel Cheng , Ph.D.
PeproMene Bio, Inc.
Hazel.Cheng@pepromenebio.com
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