Salute e Benessere
Pierre Fabre Laboratories and Scorpion Therapeutics Announce First Patient Dosed in Phase I/II Clinical Trial of PFL-241/STX-241, a Mutant-Selective Inhibitor Intended To Treat Locally Advanced or Metastatic Non-Small Cell Lung Cancer
CASTRES, France and BOSTON , Oct. 8, 2024 /PRNewswire/ -- Pierre Fabre Laboratories, a global player in oncology, and Scorpion Therapeutics, Inc. ("Scorpion"), a pioneering clinical-stage oncology company dedicated to transforming the lives of cancer patients by redefining the frontier of precision medicine, today announced that the first patient has been dosed in a Phase I/II, first-in-human dose-escalation, dose-optimization and dose-expansion trial. This clinical trial evaluates PFL-241/STX-241, a highly differentiated, orally bioavailable, highly selective tyrosine kinase inhibitor ("TKI") targeting epidermal growth factor receptor ("EGFR") Exon 19 or 21 mutations with the co-occurring C797S mutation, a known resistance mechanism to 3 generation EGFR inhibitors.
The PFL-241/STX-241 Phase I/II trial is an open label, multi-center study that aims to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary clinical efficacy of PFL-241/STX-241 as a monotherapy in patients with locally advanced or metastatic non-small cell lung cancer ("NSCLC") harboring EGFR Exon 19 or 21 mutations with the co-occurring C797S mutation.
NSCLC is the most common form of lung cancer and EGFR mutations are one of its most common disease drivers, occurring in up to 38 percent of tumors, depending on geography .
"We are eager to begin the clinical evaluation of PFL-241/STX-241, our mutant-selective 4 generation EGFR inhibitor, a molecule with differentiated properties that we believe has the potential to become a best-in-class therapeutic option for patients developing resistance to current targeted therapy," said "The initiation of this clinical trial highlights our team's engagement and execution in strong partnership with Scorpion Therapeutics, and we look forward to demonstrating how patients could potentially benefit from this targeted therapy."
PDF: https://mma.prnewswire.com/media/2525480/Pierre_Fabre_Laboratories.pdf
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Laure Bregeon-Sgandurra
Pierre Fabre Laboratories
Laure.sgandurra@pierre-fabre.com
Scorpion Therapeutics Contacts:
Ethan Metelenis
Precision AQ
ethan.metelenis@precisionaq.com
Emiley Demick
Precision AQ
emiley.demick@precisionaq.com
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