D&A Pharma: New confirmation for sodium oxybate in the treatment of alcohol dependence: a university thesis provides new evidence and explains its efficacy in maintaining abstinence

These new studies included 1,082 patients and were conducted by Julien Guiraud and a group of international experts under the supervision of renowned professors in the field of addiction treatment:  These new studies included 1,082 patients and were conducted byJulien Guiraudand a group of international experts under the supervision of renowned professors in the field of addiction treatment:  Mannheim Medical School, University ofHeidelberg (Germany) The thesis is based on...

These new studies included 1,082 patients and were conducted by Julien Guiraud and a group of international experts under the supervision of renowned professors in the field of addiction treatment: 

Mannheim Medical School, University of Heidelberg (Germany)

The thesis is based on double-blind randomized trials and meta-analyses of eight studies that investigate the heterogeneity of within- and across-study results. These trials and meta-analyses confirm the efficacy, the good tolerance and the safety of sodium oxybate in the maintenance of abstinence, particularly in severe alcohol-dependent patients. 

Sodium oxybate has a broad mechanism of action, acting on several neurobiological systems within the brain's reward system. At therapeutic doses, sodium oxybate mimics the mechanism of action of alcohol, without its toxicity in the body, and without the problem of transfer of dependence.

Alcohol dependence currently affects 3.4% of the general population aged 18 to 64 in the European Union (EU). It is one of the main causes of morbidity (mental health conditions, cardiovascular disease, cancers, etc.) and mortality (49,000 deaths per year attributed to alcohol dependence in France)¹. In addition, the social cost of alcohol in France is estimated at 120 billion euros per year².

For 30 years, Italy and Austria have been successfully using sodium oxybate to help many patients overcome alcohol dependence. Given the urgency of the ever-growing medical need, these studies can be used to extend the marketing authorization of sodium oxybate to other EU countries, such as France, where alcohol dependence remains a major public health issue.

<sup>1. Source : Santé publique France 
2. Source : OFDT</sup>

About D&A Pharma:

D&A Pharma is a pharmaceutical company founded in 2006 by Patrice Debrégeas. The company's mission is to help people live better without their addictions. Since 2007, D&A Pharma has been developing treatments for addictions and orphan diseases. Since 2015, D&A Pharma has been developing a sodium oxybate-based drug for the treatment of alcohol dependence. D&A Pharma has provided a financial support to Julien Guiraud for the conduct of his PhD thesis and has sponsored several studies presented in the thesis (https://lnkd.in/e-km-5wz)

www.da-pharma.com

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Gildas de la Monneraye, gildas.delamonneraye@mascaret.eu

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