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GLP-1 Agonists Market to Show Impressive Growth at a CAGR of 10.8% During the Forecast Period (2025-2034) | DelveInsight
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GLP-1 agonists have emerged as a game-changing therapy for managing obesity and diabetes, offering significant benefits in weight loss and glycemic control. With obesity affecting over adults globally and type 2 diabetes impacting more than individuals, these drugs have the potential to improve the lives of millions. According to DelveInsight's consultant, there were prevalent cases of obesity (adults and children) in the US in 2024, while over incident cases were of type 2 diabetes in the US in the same year. These numbers are further going to surge, leading to an increase in the target patient pool of GLP-1 agonists, consequently driving the GLP-1 agonists market.
GLP-1 receptor agonists, initially developed for the treatment of type 2 diabetes, have demonstrated significant benefits in weight management. Drugs like (OZEMPIC, WEGOVY) and (MOUNJARO) have shown substantial weight loss effects, leading to their approval for obesity treatment. Their dual action in regulating blood sugar levels and promoting satiety has made them a preferred choice for managing both conditions simultaneously.
Beyond diabetes and obesity, GLP-1 receptor agonists are being explored for other therapeutic indications. Emerging research suggests potential benefits in conditions such as cardiovascular diseases, MASLD, and neurodegenerative disorders. For example, Novo Nordisk is investigating the use of semaglutide in treating metabolic dysfunction-associated steatohepatitis (MASH), a more advanced form of fatty liver disease. Such expanding applications are likely to drive further GLP-1 agonists market growth.
The developmental pipeline for GLP-1 agonists is highly robust. Currently, over GLP-1 agonist companies are evaluating GLP-1 agonists in various stages of development, and their anticipated acceptance in the GLP-1 agonist market would significantly increase market revenue in the next decade. Companies such as , and others are presently operating in the GLP-1 agonist market. All these players are working on their lead assets, which have the potential to change the therapeutic space.
The GLP-1 agonists segment has emerged as one of the fastest-growing drug classes in the metabolic and obesity treatment landscape, driven by unprecedented efficacy in glycemic control, weight reduction, and cardiovascular benefits. This class began its therapeutic journey with T2DM, and now companies are exploring their therapeutic relevance in chronic high-patient-burden diseases, such as obesity, MASH, and OSA, creating the potential for a multi-billion-dollar market driven by strong growth.
GLP-1s like WEGOVY & ZEPBOUND have demonstrated superior outcomes in contrast to traditional diabetes drugs, driving high adoption rates and strong patient needs. The therapeutic expansion into obesity has opened new avenues, positioning GLP-1 therapies as a cornerstone beyond diabetes, leading to an overall increase in target patients. Novo Nordisk and Eli Lilly are dominating the current market with massive brand recognition and locked-in prescriber loyalty. Novo Nordisk is solidifying its leadership in the GLP-1 agonist market with its established GLP-1 therapies, including for diabetes and for weight management. Clinical trials have demonstrated that WEGOVY delivers greater weight loss compared to competitors, including , reinforcing Novo's position as a leading obesity therapy.
However, the pipeline entrants from Viking and Amgen, with a focus on sustained release and low GI intolerance, are poised to intensify competition in the forecast period. However, key companies such as , and others are gearing up with their respective GLP-1 therapies to capture a significant share of the GLP-1 agonists market.
Companies are also exploring combination therapies, novel delivery systems, and indications beyond type 2 diabetes and obesity, aiming to expand the market potential. Strategic partnerships, acquisitions, and robust clinical pipelines are expected to accelerate market penetration, challenging the current duopoly of Novo Nordisk and Eli Lilly and reshaping the global GLP-1 agonists market landscape in the coming years. GLP-1 therapeutics represent the most scalable blockbuster opportunity with multiple indication potential, strong consumer pull, and payer willingness to expand coverage. This segment is on track for a triple-digit billion-dollar market size, creating unprecedented growth visibility and competitive intensity.
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The GLP-1 clinical pipeline is highly competitive, with over 100+ active therapies in development globally. Approximately 25+ emerging candidates are in mid-to-late phases (Phase II–III), while about 30+ are in early stages of development (Phase I or Preclinical). The competitive environment is intensifying, with (MOUNJARO, ZEPBOUND) and (OZEMPIC, WEGOVY) leading the market while other entrants, such as , , , are advancing oral and next-generation GLP-1 agonists.
New modalities are moving through late-stage trials and will determine whether the market remains concentrated or fragments. This robust pipeline signals intense competition, rapid innovation, and strong potential for market disruption beyond diabetes into obesity, MASH, and cardiometabolic indications. A few of the noteworthy drugs to watch out for are the following:
was originally developed by Chugai Pharmaceutical Co., Ltd. and licensed to Lilly in 2018, granting Lilly global development and commercialization rights. Orforglipron represents a strategic inflection point in GLP-1 therapeutics as the first truly oral, non-peptide small-molecule GLP-1 receptor agonist. It stands out for its once-daily dosing, no fasting requirements, and industrial scalability, unlocking new segments beyond the injectable-dominated obesity and diabetes markets.
In 2025, Lilly reported significant clinical progress: ATTAIN-1 (obesity) and ATTAIN-2 (obesity with type 2 diabetes) topline results were announced in August, while ACHIEVE-1 (type 2 diabetes) results were released in April. Regulatory submissions for orforglipron are planned to begin in late 2025 through 2026, positioning the drug for a potential global launch in 2026–2027.
Lilly is positioning orforglipron as a scalable, potent alternative to injectables, with its non-peptide design eliminating cold-chain requirements and gastric restrictions. This approach could make orforglipron more accessible and potentially cost-efficient compared to injectable competitors like ZEPBOUND or WEGOVY. DelveInsight analysts anticipate for the drug, with its oral administration driving strong adoption among younger patients and improving adherence, positioning it as a
is emerging as a key contender in the MASH space, leveraging its dual GCGR/GLP-1 receptor agonism to deliver both metabolic and hepatic benefits. The FDA's Breakthrough Therapy designation underscores its potential to set a new benchmark in addressing a disease with limited approved therapies and high unmet need. Phase II data demonstrated significant histological improvement and fibrosis reduction, supporting optimism for its ongoing Phase III LIVERAGE program. If late-stage data confirm efficacy and safety, Survodutide could capture first-mover advantage in dual-acting incretin-based MASH therapy, potentially expanding its role beyond liver disease into broader cardiometabolic indications. With an anticipated launch in the next few years, the drug could become a major growth driver for Boehringer in the MASH market, projected to reach tens of billions by the early 2030s.
is a biologic triagonist targeting the GIP receptor, GLP-1 receptor, and glucagon receptor designed to deliver superior metabolic benefits. It is being evaluated for type 2 diabetes, obesity, osteoarthritis, and obstructive sleep apnea, with a simultaneous submission strategy. Currently in Phase III trials, Retatrutide demonstrated a mean weight reduction of up to 17.5% at 24 weeks and up to 24.2% at 48 weeks in adults with obesity and overweight conditions, as announced by Lilly in June 2023 . Its triple-agonist mechanism offers a superior weight-loss profile compared to current GLP-1 and dual-agonist competitors, potentially making it the most effective anti-obesity agent in development
holds a potentially competitive edge through its offering both a (VANQUISH-1 & 2) and an , granting flexibility in patient preference and dosing adherence Its latest 12.2% weight-loss efficacy in 13 weeks is compelling, demonstrating rapid early results in a crowded field. Yet the high discontinuation and GI side-effect profile underline risks that temper excitement. While the injectable may offer a viable fallback, Viking's ability to refine tolerability through dose titration and positioning might determine whether it remains a disruptive successor in the oral incretin race or falters amid investor skepticism. While Viking will not beat Novo or Lilly to market, it could position itself as a cost-competitive or niche player in the oral GLP-1/GIP space, leveraging payer dynamics and combination therapy opportunities.
The anticipated launch of these emerging therapies are poised to transform the GLP-1 agonists market landscape in the coming years. As these cutting-edge therapies continue to mature and gain regulatory approval, they are expected to reshape the GLP-1 agonists market landscape, offering new standards of care and unlocking opportunities for medical innovation and economic growth.
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The GLP-1 agonists report provides the total potential number of patients in the indications, such as Type 2 Diabetes, Obesity, OSA, MASH, Alzheimer's Disease, and others. Type 2 diabetes mellitus represents more than 85% of all diabetes cases globally. In 2024, more than million adults were living with the condition, and in the United States alone, around new cases are diagnosed each year. Whereas, more than people suffered from obesity last year in the US.
The GLP-1 agonists market report is a comprehensive and specialized analysis, offering in-depth epidemiological insights for the study period 2020–2040 across the leading markets, including the US, EU4 ( Germany , France , Italy , and Spain ), the UK, and Japan . The GLP-1 agonists target patient pool is segmented into:
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report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key obesity companies, including among others.
report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key diabetes companies, including among others.
report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key MASH companies including among others.
report deliver an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the market trends, market drivers, market barriers, and key Alzheimer's disease companies including among others.
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