TREEFROG PRESENTS DATA FROM THEIR PARKINSON'S DISEASE CELL THERAPY PROGRAM AT THE 29TH WORLD CONGRESS ON PARKINSON'S DISEASE AND RELATED DISORDERS (IAPRD) IN LISBON

"We are excited to present the data to the scientific community at the IAPRD for the first time. Pioneering work in the 1990s using human fetal midbrain has already demonstrated that cell therapy can bring real clinical benefits to patients [5] and, in the last decade, an increasing number of trials have been launched using pluripotent stem cells as a more standardizable cell source." says Jens Schroeder, Chief Medical Officer, TreeFrog Therapeutics. "Cell therapy has the potential to open an avenue for functional recovery where no therapy options exist. The data we are presenting reports on the first bioproduction of a cell therapy for the disease in a scalable bioreactor. In pre-clinical models, full behavioral recovery was observed by 16 weeks post transplantation and dopaminergic neurons were seen projecting into the host striatum."

"We are excited to present the data to the scientific community at the IAPRD for the first time. Pioneering work in the 1990s using human fetal midbrain has already demonstrated that cell therapy can bring real clinical benefits to patients [5] and, in the last decade, an increasing number of trials have been launched using pluripotent stem cells as a more standardizable cell source." says Jens Schroeder, Chief Medical Officer, TreeFrog Therapeutics. "Cell therapy has the potential to open an avenue for functional recovery where no therapy options exist. The data we are presenting reports on the first bioproduction of a cell therapy for the disease in a scalable bioreactor. In pre-clinical models, full behavioral recovery was observed by 16 weeks post transplantation and dopaminergic neurons were seen projecting into the host striatum."

The off-the-shelf therapy in development by TreeFrog uses their proprietary technology, C-Stem™, a breakthrough technology that addresses critical challenges of producing high quality, cell therapies at scale, efficiently. The closed system enables both the amplification and differentiation of cells. The Parkinson's program is the first application of this technology using induced pluripotent stem cells (iPSC) that are differentiated into ready-to-graft 3D microtissues containing mature dopaminergic neurons.

Details of presentation:

Guided poster tour - PD Therapy #P_03 (GPT)
Date & time: 20 May 2024 @ 15:30-16:30

www.treefrog.fr

[1] Data on file. Poster #P_03 (GPT) IAPRD 2024
[2] Statistics | Parkinson's Foundation
[3] Parkinson disease (who.int)
[4] www.parkinsons.org.uk
[5] Lindvall et al 1989, Lindvall et al 1990, Freed et al 1992

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Chief Communications Officer
TreeFrog Therapeutics 
Rachel Mooney
Rachel.mooney@treefrog.fr 

 

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