Scienza e Tecnologia
PEP-Therapy and Institut Curie granted approval from ANSM to start first-in-human clinical trial of PEP-010 for the treatment of advanced solid tumors
The clinical trial, named 'CleverPeptide', is an open-label, non-controlled, multicenter, dose escalation, Phase I clinical trial with an expansion Phase. This Phase Ia/b study has been designed to evaluate the safety, tolerability, pharmacokinetics and preliminary antitumor activity of intravenous PEP-010, administered as a single agent and in combination with paclitaxel in patients with recurrent and/or metastatic solid tumors, and in particular in Triple Negative Breast Cancer (TNBC) and Ovarian Cancer (OC).
This study is sponsored by Institut Curie and led by Pr. Christophe Le Tourneau , Medical Oncologist at Institut Curie and Head of Department of Drug Development and Innovation (D3i), and Principal Investigator of the trial.
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The study will be conducted in three clinical centers in France : Institut Curie, Gustave Roussy and the François Baclesse Center.
PEP-Therapy is a French biotechnology company developing first-in-class peptides as targeted therapies in oncology based on the Company's innovative ell enetrating and nterfering eptides (CP&IP) technology. These innovative molecules penetrate cells and specifically block relevant intracellular protein-protein interactions, leading to the inhibition of key pathological mechanisms without altering physiological mechanisms.
Founded in January 2014 , PEP-Therapy builds on research from Sorbonne University and Institut Curie. Since its inception, PEP-Therapy has raised €3,7 million from Quadrivium 1 Seed Fund, managed by Seventure Partners, and from Dr Bernard Majoie , former Chairman and CEO of Laboratoires Fournier, Founding Chairman of Fournier-Majoie Foundation for Innovation (FFMI).
For more information, please visit www.pep-therapy.com
Institut Curie, France's leading cancer center, combines an internationally-renowned research center with a cutting-edge hospital group that treats all types of cancer, including the rarest. Founded in 1909 by Marie Curie , Institut Curie employs 3,600 researchers, physicians, and health professionals across three sites ( Paris , Saint-Cloud, and Orsay), working on its three missions: treatment, research, and teaching. A private foundation with public utility status, Institut Curie is authorized to receive donations and legacies, and thanks to the support of its donors, is able to make discoveries more quickly, improving treatments and quality of life for patients.
For more information, visit: www.curie.fr
PEP-Therapy
Antoine Prestat, CEO & co-founder
hello.pep@pep-therapy.com
+33 1 81 70 76 82
Citigate Dewe Rogerson
Sylvie Berrebi , Nathaniel Dahan
PEP-Therapy@citigatedewerogerson.com
+44 (0)7714 306525
Institut Curie:
Elsa Champion , Press Relations Officer
elsa.champion@curie.fr
+ 33 7 64 43 09 28