Salute e Benessere
BioArctic announces global license agreement with Bristol Myers Squibb for BioArctic's PyroGlutamate-amyloid-beta antibody program
BioArctic's PyroGlu-Aβ antibody program consists of novel antibodies targeting a specific truncated, pyroglutamate modified form of amyloid-beta. Monomers of PyroGlu-Aβ are highly prone to aggregate, leading to the formation of harmful aggregates which cause debilitating cognitive and other symptoms in Alzheimer's disease.
The agreement includes both the BAN1503 and BAN2803 antibodies. BAN2803 includes BioArctic's transferrin receptor (TfR), a protein facilitating transport
"I am very excited about the agreement with Bristol Myers Squibb. They share our passion for helping patients with Alzheimer's disease and I look forward to having them as our partner for this program," said Gunilla Osswald , CEO at BioArctic. "With the BrainTransporter technology, BioArctic has the capability to lead in the design and development of the next generation of treatments for various brain disorders, offering the potential of faster uptake, improved efficacy, less side effects and lower doses for the benefit of both patients and society."
"Our agreement with BioArctic has the potential to further strengthen and diversify our growing neuroscience portfolio, reinforcing our commitment to exploring novel and potentially transformative approaches for Alzheimer's disease where high unmet needs remain," said Richard Hargreaves , Senior Vice President and Head of Bristol Myers Squibb's Neuroscience Thematic Research Center. "We look forward to building on our existing expertise and leveraging cutting edge innovations, like BioArctic's BrainTransporter technology, to advance and optimize the development of anti-amyloid-beta antibody treatments."
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Oskar Bosson , Vice President Communications and Investor Relations
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Charlotte af Klercker, Director Communications and Sustainability
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BioArctic's BrainTransporter technology is a technology for facilitating the passage of biological drugs as for example antibodies into the brain using the transferrin receptor (TfR). Active transport of biotherapeutics across the blood brain barrier can result in broader brain distribution enabling better efficacy, improved safety profile and dosing convenience. The technology is being applied to several in-house drug projects and could become part of future collaborations with other pharma companies.
BioArctic AB (publ) is a Swedish research-based biopharma company focusing on innovative treatments that can delay or stop the progression of neurodegenerative diseases. The company invented Leqembi® (lecanemab) - the world's first drug proven to slow the progression of the disease and reduce cognitive impairment in early Alzheimer's disease. Leqembi has been developed together with BioArctic's partner Eisai, who are responsible for regulatory interactions and commercialization globally. In addition to Leqembi, BioArctic has a broad research portfolio with antibodies against Parkinson's disease and ALS as well as additional projects against Alzheimer's disease. Several of the projects utilize the company's proprietary BrainTransporter™ technology, which has the potential to actively transport antibodies across the blood-brain barrier to enhance the efficacy of the treatment. BioArctic's B share (BIOA B) is listed on Nasdaq Stockholm Large Cap. For further information, please visit
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https://news.cision.com/bioarctic/r/bioarctic-announces-global-license-agreement-with-bristol-myers-squibb-for-bioarctic-s-pyroglutamate,c4084695
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