Salute e Benessere
Resolution Therapeutics Announces Presentation at Keystone Symposia on Fibrosis
Details of the poster presentation:
: Nonclinical program to enable a Phase1/2 trial of engineered pro-regenerative macrophages for the treatment of end stage liver disease.
: 1044
: Poster Session #1, 9 of December, 7:30:00 PM (GMT -8)
: Keith Sutton , PhD – Director, Pre-Clinical Development at Resolution Therapeutics
RTX001 is an engineered autologous macrophage therapy with enhanced anti-fibrotic and anti-inflammatory effects. The product candidate is engineered with IL-10-MMP9 mRNA to enhance the natural regenerative properties of macrophages for superior efficacy and durability. RTX001 is being tested in the Phase 1/2 study called 'EMERALD', an open-label first-in-human study in end-stage liver disease measuring clinical events as the primary efficacy endpoint. The EMERALD study is now recruiting.
EMERALD is a first-in-human, open-label Phase 1/2 interventional study assessing the safety and efficacy of RTX001 in patients with end-stage liver disease who have recovered from a recent hepatic decompensation. It is conducted in the UK and Spain and began recruiting patients in October 2024 . For more information, please visit https://resolution-tx.com/patients/
Resolution Therapeutics is a clinical-stage biopharmaceutical company focused on pioneering regenerative macrophage therapy in inflammatory and fibrotic diseases. The Company leverages its proprietary platform to develop macrophages with pro-regenerative properties for superior patient outcomes. Resolution's initial focus is on developing RTX001, its lead product with first-in-class potential supported by preclinical data demonstrating anti-fibrotic and anti-inflammatory advantages relative to non-engineered macrophages, to treat patients with end-stage liver disease. The Company is also advancing efforts to expand the potential of its platform into inflammatory and fibrotic indications beyond liver disease, including graft-vs-host disease (GVHD) and lung fibrosis. Resolution, a spinout from Professor Stuart Forbes's lab at the University of Edinburgh , is based in Edinburgh and London . Learn more by visiting https://resolution-tx.com/ and engage with us on LinkedIn.
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