Neurolief Announces Publication of Groundbreaking MOOD Study Demonstrating Efficacy of Home or Clinic-Based Neuromodulation Therapy for Major Depressive Disorder

Key Findings: Key Findings: "This publication marks a major milestone for both Neurolief and for the field of mental health," saidScott Drees, Chief Executive Officer at Neurolief. "The MOOD study validates our vision of delivering effective, accessible, and personalized neuromodulation therapy to patients suffering from MDD. We are now one step closer to makingProliv™Rxavailable to millions in need." Dr.Linda Carpenter, Principal Investigator of the MOOD study, added: ...

Key Findings:

"This publication marks a major milestone for both Neurolief and for the field of mental health," said Scott Drees, Chief Executive Officer at Neurolief. "The MOOD study validates our vision of delivering effective, accessible, and personalized neuromodulation therapy to patients suffering from MDD. We are now one step closer to making Proliv™Rx available to millions in need."

Dr. Linda Carpenter, Principal Investigator of the MOOD study, added:

"The need for new treatment options for those battling treatment-resistant depression is urgent and unmet. Proliv™Rx offers an accessible and effective solution for patients whose depression is unresponsive to medications, many of whom have endured years of persistent symptoms. This therapy has the potential to become an essential tool in the mental health treatment landscape."

The MOOD study builds on Neurolief's commitment to advancing non-invasive brain therapies. The Proliv™Rx system, which received FDA Breakthrough Device Designation, integrates adaptive stimulation with remote monitoring via a dedicated app and cloud-based analytics platform.

The full manuscript, titled "A Novel Home-Based Neuromodulation Therapy for Major Depressive Disorder: Efficacy and Safety Results from a Multicenter Randomized Sham-Controlled Study," is in press at Brain Stimulation: https://doi.org/10.1016/j.brs.2025.08.022 

About Neurolief
Neurolief is a pioneering neuromodulation company committed to developing breakthrough therapies for mental health and neurological disorders. The company has developed the world's first wearable, non-invasive, multi-channel brain neuromodulation system, that is designed for home use, engineered to simultaneously stimulate key neural pathways in the head to modulate brain regions involved in the regulation of mood and pain. Neurolief's technology is currently FDA-cleared and CE-marked for the treatment of migraine, and the company is actively seeking regulatory approvals for Proliv™Rx, its flagship product for the treatment of Major Depressive Disorder. If granted, Neurolief will be the first medical device company to offer an FDA-approved MDD treatment that can be delivered outside of the clinic. Learn more at: www.neurolief.com

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